If you have Research skill, be sure to investigate the first Hybrid Organ you find. With enough agility, you'll be able to deal damage to them safely using melee weapons while stepping backwards. Alternatively, you can backtrack while they charge. Your best bet is to circle-strafe around them and attack using your Wrench or another melee weapon chances are you'll take little to no damage in the process. Although their lack of a ranged attack might suggest that taking them out from a distance is preferable, their low attack speed makes them easy to kill even in close combat. Hybrids are generally slow-moving, and are limited to a melee attack, courtesy of the Lead Pipes they carry. They are fairly easy to dispatch, and are limited to melee attacks. They make up the majority of enemy resistance on MedSci Deck, and typically appear on every other level, albeit in significantly reduced numbers later into the game.

Hybrids are humans who have been infected by the parasitic Annelids, and mutated into monsters in service of the Many. The Pipe Hybrid is the first enemy encountered in System Shock 2, and one of the least threatening.

System shock wiki tommy